After a short slump, Cyrus finally has its own highlight moment again. The smart factory in Liangjiang New District is the main production base of Cyrus Automobile, and now it is fully loaded 22 hours a day.

This is due to the popularity of new models. AITO’s new M7 has exceeded 90,000, and even the unlisted M9 orders have exceeded 30,000.

Sailis Automobile is a leading enterprise in the automotive industry in Chongqing and Liangjiang New Area. In 2021, Sailis Automobile and Huawei jointly designed the "Smart Choice Vehicle" model, creating a precedent for cross-border cooperation between new energy automobile enterprises and ICT technology enterprises. It also opened up a new path for the booming Chinese new energy automobile industry.

Relying on this, Cyrus Automobile is playing an increasingly important role in building a world-class intelligent and connected new energy vehicle industry cluster in Chongqing. "In the past year, Cyrus Automobile has achieved a breakthrough in the new energy vehicle business from 0 to 1. In the future, we strive to achieve accelerated development from 1 to N." said Zhang Xinghai, chairperson (founder) of Cyrus Automobile.

"Back from the Dead."

From the second half of 2022 to the first half of this year, Cyrus suffered a serious sales decline, and the ensuing market doubts were also frequent.

In the face of difficulties, Zhang Xinghai chose to rise to the challenge – on the one hand, Sailis Automobile and Huawei formed a closer cooperation, and jointly established the "AITO Inquiry and Sales Service Joint Working Group", responsible for the end-to-end closed-loop management of marketing, sales, delivery, service and other businesses. On September 22, Sailis CARE Care Service Strategy was officially released, opening the era of Smart Service 3.0, and will be committed to building a full-link smart service system that runs through pre-sales, delivery and after-sales.

On the other hand, it is also more important. By continuously enriching the product matrix, Zhang Xinghai hopes to rebuild the confidence of the outside world in the increasingly fierce market competition.

On September 12, AITO asked the new M7 was listed, and in the following 64 days created a record of 90,000 vehicles in Dading. According to Zhang Xinghai, in December this year, asked the M9 will also be listed.

In order to ensure delivery, Sailis Automotive Smart Factory is making every effort to accelerate production capacity improvement. The entire supply chain has added 1 billion yuan and 20,000 more manpower. At present, AITO’s new M7 is being produced in batches, efficiently and steadily, and delivery has also been opened in many cities across the country.

Under a series of measures, the sales of Cyrus cars have finally turned around: in October 2023, the AITO series delivered 12,700 new cars, including 10,547 new cars for the new M7, and the monthly delivery of a single model exceeded 10,000, setting a record high.

This made everyone breathe a sigh of relief. Yu Chengdong, executive director of Huawei, CEO of End Point BG, and chairperson of Smart Car Solutions BU, even wrote a late-night post: "It’s not easy to come back to life!"

Zhang Xinghai said, "In the past year, Cyrus Automobile has achieved a breakthrough in the new energy vehicle business from 0 to 1. In the future, we strive to achieve accelerated development from 1 to N."

Three principles define the development code

In 1986, Zhang Xinghai founded Chongqing Baxian Phoenix Electric Spring Factory and began to cut into the field of automotive parts such as automobile shock absorbers. Since then, he has been deeply involved in the automotive industry for 37 years.

"From independent entrepreneurship to joint venture vehicle manufacturing, and then to cross-border business cooperation, we have always focused on physical manufacturing companies, constantly seeking survival, change, and upgrading." Zhang Xinghai said.

In the process, he summed up the "three insistences" – "adhere to innovation-driven, adhere to long-term, adhere to commercial success", and use them as the development principles of Cyrus Automotive.

More specifically, "adhering to innovation-driven" means to provide users with the ultimate product experience through technological innovation, product innovation and business model innovation, so as to promote the development of enterprises; "adhering to long-term doctrine" means to always focus on the physical manufacturing industry, with the blessing of core technologies, to further promote the quality-focused strategy, to provide users with the ultimate service throughout the life cycle of the car; "adhering to business success" means to first enable users to succeed, serve users wholeheartedly, and meet users’ yearning for a better car life. At the same time, actively build an all-connected car ecosystem, form a closed-loop business, drive the success of all ecological parties, and share the fruits of development.

The cooperation with Huawei reflects these three principles. The smart selection model jointly created by both parties has also brought a new idea to the development of China’s new energy automobile industry.

In 2021, Sailis and Huawei jointly launched an intelligent range extension/pure electric platform based on DriveONE, and in April of the same year, the two parties signed a new energy vehicle cooperation agreement. Under the smart selection mode, Huawei will deeply participate in product definition, styling design, marketing, user experience and other links, and work with car companies to build complete vehicles.

In Zhang Xinghai’s opinion, Sailis Automobile is Huawei’s most stable, most reliable and deepest partner, responsible for the research and development of new cars, intelligent manufacturing, service and creating a pleasant car experience throughout the life cycle; Huawei is an important integrator of software products in the Sailis automotive industry chain, empowered by core software and hardware technologies such as electrification and intelligent parts, and the advantages of both parties are complementary and win-win.

This in-depth cooperation has also given Cyrus more confidence to face competition head-on. At present, with the strong support of national policies, Chinese auto brands are achieving industrial lane change and overtaking through new energy transformation. However, the global new energy vehicle market landscape is far from certain. Some multinational car companies have awakened and begun to transform, and the competition in the global new energy vehicle market is becoming more intense.

"The new energy vehicle track is a marathon, with heavy assets and long-term investment. Finally, it must be a competition of technological innovation system and intelligent landing." Zhang Xinghai said.

It is worth mentioning that Sailis Automobile has invested more than 20 billion yuan in the field of new energy vehicles, of which the AITO project has invested more than 12 billion yuan. In June this year, AITO’s 100,000 car was officially rolled off the production line in Liangjiang New Area, becoming the fastest new energy vehicle brand to achieve this result.

He said that in the next step, Cyrus Automobile will continue to strengthen cooperation with important integrators of software-related products in the industrial chain, such as Huawei, and continue to deepen "software-defined vehicles" to help build an automotive powerhouse.

　　"Your AI data manager, help you do business together!" Recently, the Ele.me retail merchant SAAS platform "Aoxiang" officially released the "AI business assistant" function for merchants in the retail industry. Through this new business tool, merchants can intelligently generate various business key reports and key data, further enhance business capabilities and seize business opportunities.

　　This business management tool driven by artificial intelligence technology integrates advanced natural language processing, intelligent decision support and deep learning capabilities, which can provide businesses with a full range of business services including weekly report push, index change attribution, competition for business alignment, and market trend selection.

　　AI technology solves business pain points

　　"Hello, I am your AI business assistant, welcome to our platform. I will provide you with weekly report analysis, intelligent interpretation and market opportunity suggestions to make your business decisions more informed." On Monday morning, Mr. Xu, the retailer of Ele.me warehouse store, opened the new version of the Aoxiang APP and found that a new business tool was launched in the upper right corner. After clicking the "View Business Weekly Report" button, the business status of his store in the past week was clear at a glance.

　　The reporter found that the intelligent weekly report generated by the "AI business assistant" not only includes core indicators such as the valid order amount of the store, the number of valid orders, and the estimated gross profit of the store, but also includes intelligent interpretation and overall business suggestions provided by artificial intelligence based on the business operation. For example, through the operation change indicators, the "AI business assistant" will judge which indicators may be abnormal according to the historical data of the merchant. The merchant can see the data fluctuations about the net sales volume of the store, the number of goods on the shelves, the original price of the delivery fee, and the platform bears the delivery fee. Further check the reasons for the fluctuation of the data, and adjust the business strategy accordingly.

　　In addition to its own business diagnosis, the "AI business assistant" can also help merchants further analyze the surrounding business opportunities in the business district where the store is located, as well as the overall market opportunities.

　　According to the introduction, through the "AI operation assistant", merchants can query the corresponding business district according to the specific store, find the surrounding TOP stores, and compare the monthly sales of goods in the shelf rate, out-of-stock return rate, product low price rate, performance timely rate, and manual reply timely rate. These analyses can provide store managers with operational optimization suggestions and the fastest way to grow orders.

　　In addition, the "AI management assistant" can also mine the most promising products in the business circle where the store is located, and provide merchants with product opportunity analysis and product selection suggestions. At the same time, the AI will also provide operators with corresponding sales strategies based on the data.

　　The first batch of application merchants: AI is really fragrant

　　The reporter learned that, as an all-channel service SAAS platform for Ele.me retail merchants, Aoxiang has been the first in the industry to launch AI business tools after researching operators of different sizes, different industries, and different entry times. On the basis of the large model, the "AI business assistant" can disassemble the key data of store operations, and combine natural language to provide merchants with logical and clear data indicators and easy-to-understand business suggestions in a conversational mode.

　　The first batch of merchants to use "AI business assistants" also expressed "AI really fragrant" in the face of convenient new functions.

　　"The weekly report is really practical, and there is no need to summarize the data one by one for the weekly store review." Welcome Supermarket operates dozens of stores, and the person in charge of its operation said that the "AI management assistant" can quickly locate the problem through the index change, directly saving itself the time to locate the store problem. In addition, the indicators of the surrounding competition analysis are also selected accurately, which is the core focus of its daily operation.

　　Beiku Convenience said that although the number of stores it operates is not large, it feels that "weekly reports and data changes are very helpful" after using the AI business assistant, which allows merchants to quickly extract effective indicators from complex indicators and summarize them. The presentation of data and suggestions is also very intuitive.

　　"In the process of daily serving retail merchants, especially small and medium-sized merchants, we feel that merchants have obvious pain points in starting their business, obtaining industry data and analyzing business reports. Now through artificial intelligence data acquisition and analysis, merchants can effectively solve these pain points." Wang Xiaojie, head of Ele.me "AI business assistant", said that this new function is currently open to all Aoxiang merchants. Merchants can use the latest version of the Aoxiang APP. In the future, "AI business assistant" will also be gradually opened to all merchants in the retail industry in the form of tools to help merchants see their own business data.

　　On April 18, the First Chongqing Second Symposium on the Integration of Ideological and Political Education in the Shuangcheng Economic Circle of Chengdu and Chongqing was held in Dadukou District, Chongqing.

　　"Why choose Dadukou?" On May 23, 2023, during the fourth "National Mainstream Network Media Chongqing Education Tour" event, more than 40 mainstream network media reporters from across the country walked into Dadukou and asked questions.

　　It is understood that in recent years, Dadukou District has closely focused on the fundamental task of building morality and cultivating people, focusing on key issues such as "building an ideological and political curriculum system that keeps pace with the times" and "strengthening the ideological and political teaching team". From the perspective of the region as a whole, it has explored the overall promotion and implementation strategy of building ideological and political courses in large, medium and primary schools, established an education system of "Party building leads the course of ideological and political" in the region, and further promoted the integration of ideological and political education in large, medium and primary schools in the region, creating a "Dadukou model" for regional ideological and political education.

　　

Chongqing large, medium and small ideological and political courses integration construction teaching seminar exchange display

　　Same Direction: Raising Awareness and Deeply Understanding the Importance of Ideological and Political Education

　　Dadukou District has thoroughly implemented the discussion of "Ideological and political courses are the key courses for implementing the fundamental task of building morality and cultivating people", and invited experts from the Municipal Academy of Education Sciences and relevant universities to carry out theoretical training on "Party building leadership, ideological and political courses" and follow-up guidance in the whole process, so as to effectively improve the theoretical understanding and practical ability of teachers in the district.

　　After the release of the "Several Opinions on Deepening the Reform and Innovation of Ideological and Political Theory Courses in Schools in the New Era" by the General Office of the Central Committee of the Communist Party of China and the General Office of the State Council, Dadukou District, under the guidance of experts from the Municipal Academy of Educational Sciences and relevant universities and colleges of Marxism, took "coordinating the integrated construction of ideological and political courses in large, medium and primary schools" as one of the basic principles for the reform and innovation of regional ideological and political courses, and enhanced the "new efficiency" of bacon soul casting for

　　Same frequency: active practice, in-depth planning of ideological and political education curriculum system

　　Dadukou District actively explores the establishment of a party building education mechanism, adheres to the principle of "party building leads, curriculum ideology and politics" in all disciplines, and forms a number of party building and united front characteristic courses to ensure that the party branch leads the ideological and political construction of the course.

　　In terms of actively building special party building projects, Dadu District closely integrates party building with curriculum ideological and political teaching and research activities, and around the theme of "curriculum ideological and political", it has carried out in-depth classroom teaching training, high-quality class competitions, thesis and case evaluation, homework design evaluation, project research and other actions. It has created a series of special party building projects of "1 (District Teacher Training College) + N (Primary and Secondary Schools) Party Building + Teaching and Research", which projects to drive teachers’ awareness and ability of curriculum ideological and political.

　　For cultivating the typical ideological and political model of the tree selection course, we will give full play to the exemplary and leading role of the ideological and political education model school, excellent teaching team, and excellent course examples, and cultivate a group of "party building leadership, curriculum ideological and political" backbone teachers in the form of "dual training" in the form of demonstration, assistance, and bonding. This will drive the integration of ideological and political education in primary and secondary schools in the region.

　　At the same time, enrich and enrich the content of ideological and political education, and integrate into the "1 + 2 + X" series of ideological and political courses, patriotic love for the party and revolutionary traditional education, Chinese excellent traditional cultural education, national sovereignty education, rule awareness and democratic rule of law education, daily life civilization education, ecological ethics education, international perspective education, labor education, mental health education and other elements to form a broad vision of ideological and political courses and strengthen the advantages of curriculum education.

　　

Cross-regional Primary School Ideological and Political Course Construction Seminar

　　Peers: keep integrity and innovation, deeply empower the professional growth of ideological and political teachers

　　Dadukou District hired experts and scholars to teach teachers of ideological and political courses to improve the effectiveness of training. The "Curriculum Ideology and Politics" workshop for primary and secondary political disciplines carried out a series of activities such as special lectures, discussion exchanges, teaching design, paper selection, and high-quality course competitions, forming a regional "Great Ideology and Politics" atmosphere, which promoted the great improvement of ideological and political teachers in terms of professional ability, theoretical literacy, and teacher ethics and ability. Pay equal attention to training, and press the "fast-forward button" for the growth of ideological and political teachers.

　　At the same time, establish and improve the system of access, exit, rotation training, and lesson preparation for teachers of ideological and political courses in primary and secondary schools, explore the formation of the "554" mixed teacher training model and the "double-layer three-ring five-mechanism" strategy, and adopt the "123N" immersive training method. A relatively complete teacher training system has been formed, ensuring that the "big ideological and political" training of "ideological and political courses everywhere in the classroom" has strengthened the kinetic energy and focused on development, realized the development of training and training, and paved the "fast lane" for the growth of ideological and political teachers.

　　Not only that, Dadukou District also attaches great importance to training practical task design, strengthening theme research to improve teaching and research capabilities, optimizing the training staff’s echelon training, doing a good job in regular teaching and research in the form of case study, "mentoring" to do practical grinding lessons and prepare lessons, etc., effectively transforming training efficiency into teachers’ classroom teaching ability, promoting teachers’ professional development with high quality, ensuring that the "salt" of ideological and political education is subtly integrated into the "water" of classroom teaching, and achieving the "big ideological and political" goal of "curriculum doors talk about ideology and politics". Practice is parallel, opening a "new track" for the growth of ideological and political teachers.

　　Regional Ideological and Political Quality Course Competition

　　Synchronization: Collaborative development, in-depth implementation of the overall promotion strategy of ideological and political education

　　Dadukou District has improved the integrated teaching and research within and between sections, and within and between schools, forming a new type of ideological and political course practice education model that is organically unified with "in-class + out-of-class", "in-school + out-of-school", "perceptual + rational" and "online + offline". It has formed a three-dimensional mixed training model for ideological and political courses in elementary and high schools in the region.

　　The classic cases of regional teachers’ ideological and political education teaching were selected as the typical experience of the Ministry of Education for 6 times, and the first lesson of excellent teaching resources "Tree of Yidu" was pushed by the Xuexi Qiangguo platform, and the click through rate reached more than 60,000 times; the Municipal Academy of Education’s ideological and political research activities showed 12 excellent cases of ideological and political courses, and 10 ideological and political micro-lessons were selected.

　　Hosted and co-organized a series of activities such as "Yunnan, Guizhou, Sichuan and Chongqing Cross-regional Primary and Secondary School Ideological and Political Course Teaching Seminar", the first "Chongqing University, Middle and Primary School Ideological and Political Course Integration Construction Teaching Seminar", "Ecological Civilization Construction Theme Education Exchange Exhibition Activity", "Chongqing Primary School Science Curriculum Ideological and Political Exhibition and Exchange Activity", etc., with high social reputation.

　　The 2021 Chongqing Teaching Achievement Award "Development and Implementation of Regional Rule of Law Course <" Sister Sha "Entering Campus >" and the first prize "Research on Regional Overall Promotion Practice of Ideological and Political Courses in Primary and Secondary Schools" have been selected for the 2022 National Teaching Achievement Award. Among them, "Development and Implementation of Regional Rule of Law Course <" Sister Sha "Entering Campus >" has been investigated and instructed more than 20 times by leaders such as the National People’s Congress, the National Committee of the Chinese People’s Political Consultative Conference, and the Supreme People’s Procuratorate, and has been written into the reports of the Supreme People’s Procuratorate for many times.

　　Together with Chongqing Normal University, the Municipal Academy of Education and Sciences and other units, it has become a key construction community for the integration of ideological and political courses in large, medium and primary schools in Chongqing, and will further explore the way and path of building a "large, medium and primary school ideological and political education integration" teaching system and practical teaching of ideological and political education in the new era, promote the high-quality and sustainable development of ideological and political education, and explore the Dadukou model of regional integration and collaborative innovation of ideological and political courses in large, medium and primary schools.

　　At present, "multi-dimensional integration, education Dadu" is becoming a beautiful business card for the people’s satisfactory education in Dadukou District. Dadukou District will take the opportunity of the integration of large, medium and small ideological and political construction, closely combine the construction goal of "Park Dadukou, Colorful Art Bay", adhere to the integration of the whole region, participate in the whole process, and promote the coordinated development, integrated development and integrated development of large, medium and primary schools’ ideological and political education in an all-round way. It will further broaden the new driving force of development, improve the new atmosphere of development, and innovate the new development mechanism, so as to provide assistance for the high-quality development of the ideological and political integration of large, medium and primary schools in the

On June 1, NIO quietly announced its May sales, and the share price fell by 0.60%. This was another decline after the share price of the second-generation ES6 fell by 9% on the day of listing. By June 5, the total market value had been less than 100 billion Hong Kong dollars.

From the head of sales/market value to the tail of new car makers, NIO only took 2-3 years.

The market value is less than half of Li Auto, which makes NIO, which lost 14.40 billion yuan last year and 44.60 billion in 5 years, on the verge of difficulties, and the cumulative loss is more than Tesla’s 15 years of establishment.

In 2022, NIO’s cash will decrease by 10 billion yuan, and as of the beginning of 2023, there will still be 40 billion yuan in cash in the company’s account. At such a "burning money" rate, I wonder how long NIO can support?

Li Bin, chairperson of NIO, actually knows very well. He said in an interview in April this year that,If this year’s work is not good, 24 years will become another 19 years, which means that NIO may be "back" in the ICU again.

After NIO went public on the Nasdaq, it once became the most valuable car company in China, and Li Bin (left) was no exception for a while.

Back in November 2020, NIO’s market value reached 72.84 billion US dollars (about 479.70 billion yuan), making it the highest car company in China in one fell swoop.

This can’t blame NIO’s current stock price, because sales are not awesome! In May this year, NIO only delivered 6,155 vehicles, a decrease of 7.6% month-on-month, ranking second to last among new car-making forces. This is the fourth consecutive month of decline, and it is getting farther and farther from the goal of "Wei 10,000".

The monthly sales of 3 models are about 10,000, and the 7 models are still around the 10,000, so NIO is dubbed "Wei 10,000".

"If NIO still 10,000 sales every month, Qin Lihong (president) and I will have to look for jobs." In early May this year, Li Bin also joked.

Li Bin and Qin Lihong are also very hard, but the high-end pure electric vehicle (above 300,000 especially above 400,000, such as ES6 plus optional super 400,000 yuan) market targeted by NIO is too small.

Regarding the problem of NIO, as the reader’s comment after the DearAuto article hit the nail on the head "Fishing where there are fish, otherwise it will be a dead end. Where there are fish? One is plug-in hybrid including range extension to solve the problem of mileage anxiety. One is to take a trolley within 150,000 to solve the problem of urban traffic, and the family has a second car. Where there are no fish, there are no fish in the more than 300,000 pure electric markets. Whether you are Wei Xiaoli, BYD Great Wall Geely, or Huawei, there are no fish. Wang Chuanfu said well, strategy is the most important, strategy is wrong, wasting money is small, wasted time is priceless."

I seriously suspect that this reader may be a Weilai owner who hates that iron cannot make steel, otherwise he will not be able to see the problem so clearly.

There is no universal standard for high-end pure electricity, which is generally considered to be more than 300,000 yuan, which is equivalent to luxury fuel vehicles.

NIO’s standard is higher – more than 400,000 yuan, and it often posted such forms last year to prove that it is a monopoly in this market.

In August last year, for example, NIO was still relatively popular, occupying the top and second place in the rankings, but the top 10 were imposed on less than 7,000 vehicles, all of which were given to NIO, and NIO could not support such a large company with more than 30,000 people.

Correspondingly, there are only 10,000 people in Ideal and Xiaopeng.

NIO also has an ET5 sedan that is more capable of playing, in the 300,000-400,000 range, the car claims to outsell BMW 3 Series, and the amount of insurance once exceeded 3 Series, but then sales fell rapidly.

In April, BMW sold nearly 12,000 3 Series, but only 4,293 ET5s, proving that the 30-400,000 pure electric market is not so optimistic.

Due to the unresolved issues of charging and battery life, pure electric vehicles are more suitable for small cars as the second scooter in the family, rather than pure electric vehicles such as NIO.

Of course, the popularity of big cars such as the Ideal L8 and D9 also shows that consumers can also pay for high-end big cars, but they are PHEVs.

The high-end is largely reflected in performance. For electric vehicles, improving performance becomes very simple, basically adding batteries and enhancing motors; while the interior is replaced by a large screen, just to see who has a larger screen and higher pixels.

The threshold has suddenly been lowered, which means that it is not as high-end valuable.

The demand for high-end pure electric cars, if there is one, is small. NIO worked hard, but to no avail. After the launch of ES6, ES8 sales plummeted; when ES7 came out, ES6 sales fell again; when ET5 came out, ET7 dropped sharply.

This is not a problem with the NIO family. Even the most powerful pure electric brand, Tesla, saw its million-dollar Model SX sales plunge after Model 3/Y came out.

Mercedes-Benz, BMW, and Audi all performed poorly in the EV market. This is definitely not an accident. It is not that these products themselves are flawed, but that the market positioning is incorrect.

"We also know that high-end pure electric is a point of no return, but we can’t change it, it’s the decision of the global headquarters," a luxury brand head told DearAuto on condition of anonymity.

In addition, after three years of epidemic attacks, consumers are not as rich as manufacturers imagine, this year, no matter how the government at all levels to stimulate, car sales are always tepid.

According to the National Bureau of Statistics, the per capita disposable income of residents in 2022 was 36,883 yuan; this year, consumers seem to be even more short of money, and even if they have it, they will not dare to spend. The fire in Zibo during the May Day holiday also proved that ordinary people are "short of money", because the cost of going to Zibo is much cheaper than that of Sanya or Lijiang.

One of the reasons why NIO stood out in the early days was that it started early and had a first-mover advantage, which won the favor of the capital markets. The second relied on the ultimate service to create a unique city and build its high-end image. The power exchange model is the core of NIO’s service system, but this core may bring down NIO.

According to industry data, the cost of NIO’s first-generation replacement stations is about 2.50 million-3 million yuan, and the cost of second-generation replacement stations is about 1.50 million yuan (excluding batteries). NIO has established 205 first-generation replacement stations, and the number of second-generation replacement stations is 1,100. In this way, NIO has invested 21.625 billion in replacement stations. Including land rent and operating costs, NIO’s investment in replacement mode has exceeded 10 billion yuan.

In 2023, NIO plans to increase the number of new power stations from 400 to 1,000, with a new investment of 2 billion yuan.

"Kneeling and licking service" has no bottom line, it is difficult to get off the service, and the car owner is also spoiled.

NIO began to do some "tricks" on the service this year, including that the beta version of NOP + Enhanced Pilot Assistance will be switched from free use to paid subscription; the power exchange benefit will be changed from the original 6 times a month to 4 times a month free and no longer send home chargers.

The "backlash" came soon, and NIO’s sales in April and May did not exceed 7,000 units.

After the second-generation ES6 went on sale, ES7 owners quit (thinking that the ES6 was too cheap, affecting the residual value of ES7 used cars) and asked NIO for compensation. The owner replied to Li Bin and said: "My relationship with you is not that close. I am here to negotiate, not to talk."

Li Bin said publicly that this is impossible because he needs to invest in real money.

High-end is the tone of NIO electric vehicles. Li Bin has repeatedly emphasized that "NIO will not offer low-end vehicles, nor will it reduce prices."

But the auto industry is an industry that pays attention to scale. Li Bin is very clear in his heart, "In the long run, the sales of 2 million cars a year by car companies are the line of life and death. If you can’t see the hope of sales to this line, I think it will be difficult."

For NIO, the top priority is to sell more cars and cut costs to survive.

Due to NIO’s high-end attributes limiting its sales scale, its second brand, Alpine, and even its third brand, Firefly, are expected to be used primarily for impulse.

Let’s not say that multi-brand operation is a huge pit, and there are few successful precedents for Chinese and foreign automakers.

For NIO, going down is more difficult because it faces stronger competitors. In addition, mid- to low-end brands have higher cost requirements, which is not good at NIO.

According to NIO’s plan, the Alps brand will mainly target the price range of 20-300,000 yuan. And it is expected that products will be launched in 2024.

But competitors in this price range include BYD, Tesla, Extreme Krypton, Wei Brand, Deep Blue, and a large number of joint-venture electric vehicles.

Firefly is NIO’s car brand, which will be launched in Europe at that time, and is expected to be in the price range of 10-200,000 yuan.

The competition in this market is even more intense in China. Not only are there a bunch of pure electric vehicles including Aian and BYD, but also a large number of plug-in hybrid models. Wuling is also a mythical existence. (Text | DA Bin)

1905 movie network news On the evening of December 22, Jiaxing Media, the brokerage company to which Yang Mi and Liu Kaiwei belong, issued a statement announcing that Yang Mi and Liu Kaiwei had signed an agreement in 2018 to peacefully break up and end their marriage.

In the statement, it also specifically stated that "although they will no longer live together as husband and wife, the two will also take care of and raise the children together as relatives in the future." To put an end to the small glutinous rice issue that the majority of netizens are concerned about.

In 2011, Yang Mi and Liu Kaiwei fell in love for the filming of the TV series "Ruyi". In 2012, the two admitted to their relationship on Weibo. On January 8, 2014, Yang Mi and Liu Kaiwei held a wedding ceremony in Bali; on January 19 of the same year, Liu Kaiwei confirmed that Yang Mi was more than three months pregnant. On June 1, 2014, Yang Mi gave birth to her daughter "Xiao Nuomi" in Hong Kong.

In the two years after their marriage, Yang Mi and Liu Kaiwei interacted frequently, and the two often forwarded and interacted sweetly with each other on Weibo. But since 2016, the interaction between the two sides on Weibo has become less and less. In the past two or three years, both of them have produced a lot of new works, but the two sides have almost never promoted each other. On December 3, 2015, Liu Kaiwei forwarded Yang Mi’s new works for the last time. And at the end of 2015, it was when Liu Kaiwei and Yang Mi reported that their marriage was changing.

Until 2018, the two’s Weibo almost stopped interacting. The last time Liu Kaiwei interacted with Yang Mi on Weibo was on April 12, 2018. Yang Mi was caught in a public welfare scam, and Liu Kaiwei forwarded the rumor-refuting article and supported Yang Mi.

And according to an online friend, "It has been rumored for so long, why did Liu Kaiwei and Yang Mi choose to announce the divorce statement today? Because schools in Hong Kong will give students a Christmas holiday from December 22, and the holiday time is not short. In order to protect Xiao Nuomi from being chased by the media, the two of them advised everyone not to disturb Xiao Nuomi."

Click to watch more video highlights of Star Jump > >

Killer took off handstand.

Xing Aowei takes off.

Gao Hu’s Flying Swallow Action

　　Zhejiang Satellite TV’s large-scale charity star diving reality show "China Star Jump", since last week’s transfer to the semi-finals of the master’s tricks, the overall difficulty of the players’ jumping has improved, and the difficulty of the movements has erupted collectively. Especially in Gao Hu and Killer, two "high-platform kings" jumped out of the amazing professional-level movements. Killer took out the difficult movement of 611A handstand and somersaulted forward for half a week in the first jump, and then challenged the highest difficulty 202A of the 10-meter platform since the launch of the diving program, while Gao Hu 302C’s perfect jump of reflexively somersaulted and hugged her knees for one week, which was praised by Olympic champion Li Na, a substitute judge, as "the height that professional athletes can only reach after practicing for one year". This week’s second semi-final is still full of experts, especially Xing Aowei, the Olympic gymnastics champion of cross-border diving, who created a dazzling 720-degree somersault and a 180-degree twist against the sky in the preliminary round. The semi-final will continue to carry forward the spirit of innovation and threatened to "jump the diving action of the next Olympic Games" if he advanced to the final.

　　Killer, Xing Aowei and Gao Hu, who are also non-professional divers, have turned from inexperienced diving novices to almost professional ones. Their respective advantages of "being in harmony with the right time and the right people" are prominent, which is an important weight for their successful breakthrough and the secret behind their successful counterattack.

　　Location: Gao Hu grew up facing the sea, and his childhood "plunge" warmed up and dived.

　　Gao Hu is the "king of the platform" among the contestants. He not only won the 10m platform at the fastest speed in training, but also was the first person in the competition. In addition to the courage and boldness of "being too high to be happy", Gao Hu showed an amazing and perfect swallow in the preliminary round, and the difficulty of the action was also upgraded all the way. Especially in the last semi-final, Gao Hu 302C made a perfect jump by doing a reverse somersault and holding her knees for a week. Even Olympic champion judge Li Na praised this as "the height that professional players can only reach after practicing for one year". He also relied on this difficult and perfect jump to sit firmly on the spot and advance directly to the final without any suspense.

　　The reason why Gao Hu achieved such amazing diving attainments in a short time can be said to be due to the "geographical advantage" occupied since childhood. He is a native of Qingdao, and the urban environment surrounded by the sea on three sides gives Gao Hu a unique advantage before diving. According to Gao Hu himself, "I grew up facing the sea, and I have a deep plot about water. My whole family likes swimming very much, so I have been moving freely in the water since I was three or four years old". According to Gao Hu’s recollection, there are many hills and rocks in his hometown near Qingdao. When he was a child, he was bold. He often avoided his parents’ attention with his friends and jumped from the rocks to the water for excitement. Although the equipment was rudimentary and there was no technical content, his childhood experience was similar to that of today’s diving, especially because he learned Gao Hu’s boldness. It is no wonder that he was able to walk calmly on the 10-meter platform on the first day of training. He once said that "I am not afraid of heights at all and like to challenge the limits." Gao Hu, who has excellent water quality, also revealed that he had passed the diving certificate when he traveled to Palau.

　　In addition, Gao Hu is also a sportsman. He likes to play volleyball since he was a child. He is the leader of the school volleyball team. He has participated in many municipal competitions with the team, and volleyball has also trained Gao Hu’s good arm strength.

　　Timing: Killer was born with good gene dance skills and was born with boldness.

　　Killer has been called "Zhang Dadan" since she entered the competition. In the preliminary competition, she was the first woman on the 10m platform, which was as famous as Gao Hu. In the semi-finals, she was even more powerful, with two consecutive jumps. The first jump of 611A turned upside down for half a week, becoming the first woman to use platform handstand, while the second jump of 202A turned backwards for a week, which was the highest difficulty since the diving program was launched.

　　The reason why Killer dives so well can be said that she won at the starting line because of her favorable weather and natural genes. Killer’s mother is a dance teacher, and her innate motor genes, coupled with the super-high physical flexibility of practicing dance since childhood, give her obvious advantages in diving. In addition, Killer, who is bold by nature, also said that he was particularly love the water and liked swimming since childhood. This boldness surprised everyone when Killer walked into the diving hall for the first time, and immediately won the 10m platform, giving the competitors a modest "duel". In a daily training, the diving hall was suddenly cut off due to an accident, and it was suddenly plunged into darkness. At that time, the staff and players present, especially the girls, screamed with fear and scrambled to climb ashore from the water. At that time, Killer, who was on the shore, jumped into the water and swam in the dark diving hall, exclaiming that "such an opportunity is too rare, swimming in the dark is very exciting", which attracted Gao Hu present to be outdone and jumped into the water.

　　People and Peace: Coach Xing Aowei and the judges all found that small gymnastics and diving are connected.

　　As the Olympic champion of gymnastics, Xing Aowei still can’t hide the champion’s potential in cross-border diving. In addition to his amazing jump in the preliminary round, he let the audience see the high platform handstand for the first time, and even created a dazzling "anti-heaven" action in the second jump: 720-degree somersault and 180-degree turn, which caused a full house of applause. This action is even more created by Xing Aowei. In the semi-finals, he said that he would continue to carry forward the spirit of innovation, and he confidently threatened to "jump the diving action of the next Olympic Games" if he could advance to the final.

　　Xing Aowei has the highest starting line among all the players. As a gymnast of the national gymnastics team and an Olympic gold medal champion, he stood out among all the players from the first day of training. The national diving team and the gymnastics team are veritable neighbors. They used to practice in the same training hall. Therefore, many national diving team members and Xing Aowei have been good friends since childhood, including Li Na, the world diving champion who is the coach in this competition. Therefore, Xing Aowei has no pressure and a sense of formality in the training process. Although gymnastics and diving are two completely different sports, they have a lot in common, especially turning and tumbling, which is why Li Xiaopeng of Prince of gymnastics was specially invited to the jury, and Li Xiaopeng’s position was to comment on diving from a semi-professional perspective. Xing Aowei and Li Xiaopeng are both Olympic champions. Since Li Xiaopeng can be a judge, it can be seen that Xing Aowei’s starting line is high, and their teammates, especially good brothers, let him score in the judges’ scoring.

　　Pay more attention to "China Star Jump" official website: http://www.zjstv.com/splash

　

Fast Technology News on June 18, the latest data released by Qjie Automobile shows that,From January 1st to June 16th, the new M7 sold 100,900 units, topping the top 1 sales list of new power models in the Chinese market.Become the first new power model to exceed 100,000 sales in 2024.

The recently released 2024 China New Power Model Sales List includes statistics on the sales of new power models from January to June this year.

The list shows that as of June 9,The annual cumulative sales of the new M7 series models have reached 96,500 units, and the cliff-type leading ideal L7, polar krypton 001 and other new power models have won the first half of 2024 China’s new power sales crown.

At the same time, the newly upgraded "National SUV" asked Jiexin M7 Ultra, with deliveries exceeding 4,349 units in the first week of listing, setting a new power model delivery record in China.

Other models in the list, the ideal L7 ranked second with 56,600 vehicles; the polar krypton 001 ranked third for 42,000 vehicles.

This is also equivalent to,The sales of the new M7 in the world have almost reached the sum of the second and third place, indicating the leading advantage of the new M7 in the world.

It is reported that the new M7 Ultra was launched on May 31, with a total of four models, priced at 28.98-32 9,800 yuan.

The new car is equipped with Huawei’s latest 192-line lidar (the same model as the M9) as standard, which is currently the highest number of line lidar in mass production. With Huawei’s mature ADS 2.0 high-end intelligent driving, there are few competitors in the same level of intelligent driving experience.

And ask the new M7 Ultra’s 35,000 yuan limited-time car purchase rights will end on June 30. It is expected that by the end of June, the order volume of the new M7 will have a big outbreak.

According to the China Fund, the pace of capitalization of the new car-making forces has obviously accelerated, and this time it is Li Shufu’s turn to be a krypton car.

On February 13th, Geely Holding (00175.HK) announced in the morning that it issued and distributed about 139 million Series A preferred shares to five investors, raising a total of 750 million US dollars (equivalent to 5.09 billion RMB). Among them, Contemporary Amperex Technology Co., Limited (300750), which has invested in the Pre-A round, has increased its price again, which shows that it is optimistic about this new force.

After completing this round of financing, the valuation of Krypton has reached 13 billion US dollars (about 88.23 billion yuan). It is understood that this valuation amount also exceeds the valuation level before landing in the IPO of the US stock "Wei Xiaoli" in the early years. As early as the end of last year, Geely publicly announced that it planned to split the IPO of Extreme Krypton in the United States, and this new force in making cars is also expected to become the first new energy vehicle company listed this year.

Contemporary Amperex Technology Co., Limited participated in the second vote.

Extreme Krypton Automobile announced the first heavyweight financing of the new energy automobile industry this year. According to the announcement of Geely Holding, Extreme Krypton entered into a share purchase agreement with five investors on February 12. Accordingly, five investors agreed to subscribe and purchase from Krypton, and Krypton agreed to issue and distribute a total of 139 million Series A preferred shares to five investors at a total consideration of 750 million US dollars.

It should be pointed out that the investors participating in this financing are Amnon Shashua, founder of Mobileye Global Inc, Contemporary Amperex Technology Co., Limited, Yuexiu Industrial Fund, Trading Fund and Xin An Zhi Fund. According to Krypton, after the completion of this A round of financing, the valuation of Krypton is about 13 billion US dollars.

This amount also exceeds the pre-IPO valuation of the three new car-making forces "Wei Xiaoli" that have been listed in the United States. The highest valuations of the above three companies were about $6.4 billion, $8.6 billion and $8.8 billion before the US stock market was issued.

Judging from the institutions participating in this round of financing, Contemporary Amperex Technology Co., Limited is not only a long-term strategic partner of Krypton, but also an additional investment in this round to further deepen cooperation. As early as August, 2021, Contemporary Amperex Technology Co., Limited participated in the Pre-A financing of Krypton cars. In addition to Contemporary Amperex Technology Co., Limited, the participating institutions in this round include Yuexiu Industrial Fund, Trade Fund and Quzhou Trust An Zhi Fund. According to Krypton, the above three companies will help Krypton integrate its rich industrial resources and help it further expand in the upstream and downstream of the industrial chain.

According to the announcement, immediately after the delivery, Geely Holding will hold approximately 54.73% (calculated on the converted basis) and approximately 51.33% (calculated on the fully diluted and converted basis). Krypton will remain an indirect non-wholly-owned subsidiary of Geely Holding, and its financial performance will continue to be incorporated into the Group’s consolidated financial statements.

According to Krypton, the funds raised this time will be mainly used for research and development of Krypton products and technologies, global business development and user experience improvement. The company said that the five investment institutions have rich industrial resources in their respective fields, especially in smart driving, power batteries, innovative materials and high-end equipment manufacturing.

Or the fastest IPO case in the cost round

In March 2021, Extreme Krypton Automobile was jointly invested and established by Geely Automobile and Geely Holding Group. Geely has also given high hopes to the extremely krypton car.

The data shows that Krypton delivered a total of 71,900 vehicles last year, and completed the sales target of 70,000 vehicles in 2022 ahead of schedule in mid-December. According to the expectation of Geely Holding Group, by 2025, the sales volume of extremely krypton vehicles will reach 650,000, ranking the top three in the world in the market share of high-end electric vehicles. Moreover, the sales performance of Krypton is completely supported by the single model Krypton 001, so the annual sales of Krypton are quite valuable.

In terms of financing, Krypton Auto completed the Pre-A round of financing with a total of US$ 500 million from Intel Capital, Contemporary Amperex Technology Co., Limited, Bili Bili, Hongshang Group and Boyu Investment in August of that year. According to the financing situation at that time, the valuation of Extreme Krypton was about $9 billion.

In December last year, Geely Holding publicly announced that on December 7, 2022, Krypton submitted a draft registration statement for possible initial public offering to the US Securities and Exchange Commission on a confidential basis. The proposed spin-off currently includes two items, namely, the sale of krypton shares in the United States and the distribution of American Depositary Shares to shareholders in kind.

Earlier, it was reported that Krypton sought to raise more than $1 billion in the United States, with a valuation of more than $10 billion, which was higher than the valuation of $9 billion when it raised funds for the first time in 2021. However, according to the valuation of this A round of financing, this amount has far exceeded previous expectations. And this new car-making force was established only less than two years ago.

It is widely speculated in the market that Krypton will be listed as soon as possible in the second quarter of this year, so it is also considered to be the most likely car company to be listed first in this round.

Years of losses to accelerate financing.

Recently, the pace of capitalization of new car-making forces is accelerating. At the beginning of this month, Hezhong Automobile behind Nezha Automobile completed the shareholding system change, which was understood by the market as accelerating the IPO. Ai’ an, a subsidiary of Guangzhou Automobile Group, also explicitly called out the IPO in 2023.

These new forces have a common feature, that is, they are in a state of loss for years. Even "Wei Xiaoli", whose sales volume has climbed and gross profit margin has turned positive, has not yet achieved profitability under the continuous R&D investment and market layout. Ceng Qinghong, chairman of Guangzhou Automobile Group, once bluntly said, "Except for Tesla, all new energy automakers are losing money and have no money to earn. This is a consensus."

In 2021 alone, the loss of Ai ‘an, which has been valued at over 100 billion yuan, reached 1.389 billion yuan, with a year-on-year increase of 101.95%. In 2019 -2021, the losses of Ai ‘an were 621 million yuan, 688 million yuan and 1.389 billion yuan respectively, with a cumulative loss of 2.698 billion yuan in three years. In 2020, the net loss of Nezha Automobile reached 1.321 billion yuan, and in 2021, its net loss expanded to 2.908 billion yuan.

Krypton cars can’t escape this fate. According to the previously published financial report data of Geely Convenience, the revenue in 2021 was 2.868 billion yuan, and the net loss in the same period reached 1.01 billion yuan; In the first half of 2022, the revenue of Krypton was 8.828 billion yuan, and the net loss during the period was 759 million yuan. Since the establishment of the brand, the accumulated net loss of Krypton is nearly 1.8 billion yuan.

The gross profit margin of this new car-making force was around 5% in the first half of last year. The gross profit margins of LI, Xpeng Motors and Weilai were 22.09%, 11.55% and 13.8% respectively.

Original title: the valuation is nearly 90 billion! Li Shufu is on fire again, Ning Wang is overweight!

Editor: Zheng Yalan

Editor: Zhang Songtao

Audit: Feng Fei

foreword

Malignant multiple myeloma(multiple myeloma ； MM) is a kind ofwithMalignant disease characterized by massive proliferation of monoclonal plasma cells in bone marrow. B cell maturation antigen (BCMA) is highly expressed on the surface of MM cells. In the past few years, great progress has been made in various BCMA targeted immunotherapy for recurrent/refractory MM patients, including anti-BCMA monoclonal antibodies, antibody-drug conjugates (ADC), bispecific T cell binders (BITE) and chimeric antigen receptor adoptive T cell therapy (CAR-T). The 63rd annual meeting of American Hematology Society updated some information about the application of BCMA in MM, and based on this annual meeting, the related contents of this paper were sorted out [1].

Immunotherapy targeting BCMA: (1)ADC; 　 (2)CAR-T; 　 (3)BiTE;　

copywriter |　NING

BCell maturation antigen (BCMA)

Also known as TNFRSF17, it is a member of TNF-receptor family, and is called tumor necrosis factor receptor superfamily 17. This receptor is expressed on the surface of B lymphocytes and plasma cells, and is a marker protein of B lymphocyte maturation. Under physiological conditions, BCMA is mainly expressed in plasma mother cells and terminally differentiated plasma cells (PC). Under pathological conditions,BCMA Almost in all MM Tumor cell line (80%–100%) are expressed.The number of BCMA on the surface of malignant PC is much higher than that of conventional PC, which explains why BCMA target has become a battleground for major biological enterprises.

Monoclonal antibody targeting BCMA

SEA-BCMAIt is a new humanized non-fucosylation. IgG1 mAb. The working mechanism of SEA-BCMA may include blocking BCMA activation and its downstream proliferation signal pathway, regulating antibody-dependent cell phagocytosis and enhancing antibody-dependent cytotoxicity.

Its clinical phase I trial (SGNBCMA-001; The preliminary results of NCT03582033) show that it has good safety and combination potential: SEA-BCMA also shows encouraging treatment duration and initial anti-tumor activity in the advanced R/R MM population who have received a lot of treatment before.

Source: blood (2021) 138 (Supplement1): 2740.doi: 10.1182/blood-2021-146047.

Bispecific T Cell cement (BITE)

BiTEs can simultaneously target BCMA on MM tumor cells and CD3ε domain of TCR on T cells. After T cells are combined with myeloma cells, cytotoxic T cells can be activated and secrete cytotoxic factors, thus producing cell killing effect.This part is still in Ⅰ at present./Phase ii.

The following table summarizes the clinical data of bispecific antibodies against BCMA, among which the BiTE bispecific type of BCMA×CD3 is the most common.

Novel trispecific antibody drugs

Researchers are no longer satisfied with treating patients with R/R MM through dual-target therapy.HPN217, an extended half-life (median serum half-life:74 Hours) three specificity. T Cell activation construct (TriTAC)It simultaneously targets BCMA and CD3ε (redirected T cells), and adds serum albumin to prolong the half-life, which can exert cytotoxic effect on myeloma cells.Currently working onR/R MM of 1 /2 Phase I clinical trial for evaluation (NCT04184050). Here are some preclinical data.

Legend: HPN217 mediates the killing effect of autologous T cells of NCG mice on BCMA-dependent/primary MM cells.

Source: blood (2021) 138 (Supplement1): 1185.doi: 10.1182/blood-2021-151880.

CDR101(CDR-lifeCompany’s products)Is simultaneous targeting.CD3、BCMAandPD-L1The trispecific antibody,T cells can be induced into tumor cells expressing BCMA, and the immunosuppressive effect caused by the interaction between PD-L1 and PD-1 can be blocked at the immune synaptic site. Compared with BCMA × CD3 bispecific drugs, CDR101 leads to at least a tenfold increase in T cell-mediated tumor cell lysis, and performs better than the combination of PD-L1 inhibitor and BCMA × CD3 bispecific drugs.CDR101 It may become a new ready-made treatment, providing a more lasting response and a higher cure rate. CDR101 Has excellent drug-like characteristics, high stability and high stability.CHOHigh yield of expression.Based on these findings, new trispecific immunotherapy drugs have high clinical potential and promising clinical application [2].

Antibody drug conjugate (ADC)

After recognizing BCMA on the cell surface, ADC internalizes it into myeloma cells. Through the degradation of lysosomes or endosomes, the payload is released, causing cytotoxicity.

Belantamab mafodotin (GSK2857916)Is targeted by humanization.BCMA IgG1 andMMAF(tubulin polymerization inhibitor). Belantamab mafodotin was approved by the US Food and Drug Administration (FDA) in 2020 to treat patients with R/R MM.This is the first target approved for listing.BCMAimmunotherapy,A multicenter phase II clinical study (NCT03525678) confirmed that the recommended regimen for patients was 2.5 mg/kg, once every three weeks, but the toxicity of the drug was mainly manifested in thrombocytopenia and pericorneal lesions, such as microcystic epithelial changes or superficial punctate keratopathy. In addition to belantamab mafodotin, several other ADCs targeting BCMA, such as AMG 224, MEDI2228 and HDP-101, have also conducted many preclinical or clinical studies at different stages.

Legend: Incidence rate of adverse events caused by Belantamab mafodotin at 2.5 mg/kg and Q3W.

Antibody drug conjugate (ADC) joint test.

In the joint experiment, there are two schemes: belantamab+DEX (dexamethasone) and belantamab+DEX+POM.

belantamab(2.5 mg/kg Q3W) and DEX(20-40 mg Q1W,threeCycle) jointAfter use, the objective remission rate (ORR) was 46%, the complete remission rate (CR) was 14%, the median progression-free survival (PFS) was 4.9 months, and the median overall survival (OS) was 7.4 months. The incidence of AEs from high to low is anemia (83%), keratopathy (82%; Gr3/4: 56%), thrombocytopenia (70%) and so on.

belantamab+DEX+POMUnion ofIn the experimental scheme, the ORR was 88.9%(48/54), and the CR and PR rates were 24.1%(13/54) and 20.4%( 11/54) respectively. However, keratopathy (96.9%) was also the most common AE, and 56.7% of such patients had reached Gr 3/4. These two studies show that POM and DEX may have a positive effect on the curative effect of belantamab. howeverKeratosis is still a challenge in the treatment process.

Legend: Detailed rules and results of belantamab+DEX (Dexamethasone) joint trial scheme.

Source: Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

CAR-Ttherapy

nowTwo CAR-T therapies based on BCMA have been approved for marketing.And is used for treating patients with multiple myeloma.

Source: "CAR-T therapy targeting BCMA"

7.1

Cilta-cel (Carvykti) for Orense injection.

Sidaki Orense injection(Cilta-cel,Carvykti) yes2022year2moon28Listed in China (NMPAApproved for listing/FDAFormal approval) targeting.BCMAofCAR-TCell products, jointly developed by Janssen and Legendary Bio, Legendary Bio owns 70% interests in Carvykti Greater China and 50% interests overseas.

In CARTITUDE-1 trial, the overall remission rate was 97%, the 18-month progression-free survival rate was 66%, and the 2-year progression-free survival rate was 61%. The 18-month overall survival rate is 81%, and the 2-year overall survival rate is 74%. Compared with similar products, this data is very gratifying. According to the latest news from Kingsley, the sales of the legendary BCMA CAR-T new drug Carvykti in the first half of the year was 24 million US dollars.

7.2

Abecma（Ide-cel）

2021yearthreemoon26Day,FDAapproveBaishimei SquibbAbecma(Ide-cel)be listedAbecma is also a BCMA-oriented CAR-T cell therapy, which is customized from patients’ autologous T cells. Clinical data show that the overall remission rate of all patients is 72%, of which the complete remission rate is 28%; Even for patients who have received various regimens, the remission rate of Abecma still reaches 72%, and this remission is very lasting, and 65% of patients are over 12 months.

Legend: preparation principle of Abecma

7.3

Iqalunsei injection

In addition, June 2, 2022Reindeer biology/Xinda biologyAnnounce BCMA CAR-T therapyIqalunsei injectionThe listing application was obtained.NMPAAccepted, it is expected to become the first domestic independent research and development of the whole process.CAR-Ttherapy. The clinical research data reported at the 63rd ASH annual meeting in 2021 showed that the overall remission rate (ORR) was 94.9%, and the complete remission rate/strict complete remission rate (CR/sCR) was 58.2%, showing the excellent safety and effectiveness of Iqalunsei injection.

Source: NMPA official website

7.4

The clinical trial of CAR-T therapy targeting BCMA is as follows

summary

Judging from the listing situation,Belantamab mafodotin (GSK2857916) is composed of humanized targeting BCMA IgG1 and MMAF (tubulin polymerization inhibitor), which is the first targeted BCMA immunotherapy approved for marketing. At present, there are two CAR-T therapies that have been put on the market, developed by Bristol-Myers Squibb respectively.Abecma(Ide-cel), developed in cooperation with Janssen)/ Legendary Biology.Sidaki Orense injectionFrom the data point of view, the latter effect is better, the ORR is increased from 72% to 97%, and other indicators are relatively better. On June 2nd, 2022, Reindeer Bio/Cinda Bio announced BCMA CAR-T therapy.Application for marketing of Iqalunsei injectionIt has also been accepted by NMPA, and it is expected to become the first CAR-T therapy independently developed in the whole process in China. Let us wait and see! From the therapeutic point of view, CAR-T therapy is at the forefront in terms of clinical data and market situation, but we can’t simply judge the advantages and disadvantages of these products. For example, better anti-BCMA CAR-T cell therapy requires more complicated preparation conditions and more expensive treatment costs, which are unbearable for ordinary families. Therefore, while continuing the existing research, it is necessary to study the potential mechanism affecting the curative effect in order to optimize BCMA targeted immunotherapy.

　 　

Legend: Comparison of clinical efficacy between different immunotherapy products targeting BCMA (see [1] for specific clinical data).

reference data

[1]Targeting BCMA to Treat Multiple Myeloma: Updates From the 2021 ASH Annual Meeting. Front Immunol. 2022 Mar 7; 13:839097. doi: 10.3389/fimmu.2022.839097. PMID: 35320942; PMCID: PMC8936073.

[2] Blood 2021; 138 (Supplement 1): 1583. doi: https://doi.org/10.1182/blood-2021-152160

[3] Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

* Tweets are used to transfer knowledge. If you have any questions about copyright, please contact BiG Bio-innovation Society within 30 days after the publication of this article.

On December 23rd, Chongqing Jin Kang Sailis announced that it had jointly launched a high-end smart car brand AITO (Chinese name: Aotu), which is a new high-end new energy brand that Huawei has chosen new products and cooperated with car companies. slogan is "A journey of thousands of miles begins with AITO"!

At today’s new product launch conference of Huawei in winter, AITO’s first model, AITO Wenjie M5, was officially launched, with a mid-to-high-end positioning, belonging to an intelligent luxury electric drive SUV (medium-sized), which was built by major teams such as Huawei’s consumer business, including system software, industrial design, engineering technology, ecology, etc., with high autonomy.

In addition, HUAWEI has specially provided Huawei’s household charging piles for new cars, which are genuine Huawei car accessories to help solve the anxiety of users.

The IT House learned that "Huawei only makes parts and does not build cars, but helps enterprises build good cars".

Yu Chengdong said that this model is far superior to other brands in terms of performance, handling and intelligent experience.

Huawei also brought its simple and ultimate industrial design concept to this car. The exterior is luxurious and compact, and the interior is spacious and comfortable, which not only allows everyone to enjoy the convenience of parking and turning around easily in the city, but also allows the main driver and passengers to have a comfortable experience even during the long journey.

With the help of the industrial concept of Huawei team, this car has achieved a simple and extreme design. First, it is equipped with an intelligent cockpit. The AITO M5 can seamlessly flow with other intelligent terminals, completely breaking through the barriers between "people, cars and homes".

In terms of software, the M5 interface of AITO Interface provides advanced sense and intelligent functions, which "surpasses all models and car enterprises", such as L2+intelligent driving assistance, HarmonyOS intelligent split screen, one-button flow, NFC Bluetooth sensorless car key of Huawei watch, 3D face recognition, automatic login to Huawei account, automatic switching of driving information, schedule, real-time updating of car navigation map, intelligent sound source perception in multi-tone area, offline voice assistant, real-time detection of fatigue state by computational vision, etc.

Huawei said that with powerful computing power and operating system, through continuous AI learning optimization and OTA upgrade, HarmonyOS Auto can meet consumers’ demand for intelligent, scene-based and personalized experience upgrade.

IT House understands that AITO Wenjie M5 has six paint colors: ceramic white, pine frost green, ice crystal gray, gold-plated black, mi navy blue and azure blue, and three interior colors: ivory white, extreme night black and agate brown, which can be freely matched.

According to Yu Chengdong, Huawei designed it according to the quality and interior requirements of millions of luxury cars, which exceeded the driving sense of 500-100 million yuan. The interior space was comparable to that of a large SUV, and the cockpit was surrounded in one piece, which perfectly interpreted the experience of "advanced feeling", "simplicity" and "immersion".

In terms of power, AITO Wujie M5 adopts front double wishbone independent suspension (anti-roll), rear multi-link independent suspension (stable), all-aluminum chassis (weight -30%), and is equipped with Huawei’s own DriveOne pure electric drive range-extending platform, which has fast acceleration, long battery life and can be powered by electricity and oil.

It is equipped with 1.5T four-cylinder range extender 3.0, asynchronous AC motor and permanent magnet synchronous motor. The peak power of intelligent four-wheel drive flagship version is 365kW(675N?m), and the performance version of four-wheel drive is 315kW. Its performance is superior, and its endurance exceeds that of Porsche, BMW X3, Mercedes-Benz GLC, Audi Q5L, Tesla Model Y and many other luxury cars, with the highest compression ratio of 15:1, ultra-high thermal efficiency of 41% and 3.

According to Yu Chengdong, this model also has extreme cornering performance, which is stronger than McLaren. In terms of acceleration, it can also achieve acceleration of 4.4 seconds at zero speed and 1.9 seconds at 0-50km/h, and its performance can crush many fuel vehicles and surpass many pure trams.

Advanced precision oil cooling technology is also adopted in AITO Interface M5, which reduces the average peak temperature of winding by 30℃ and the peak temperature of magnetic steel by 15℃.

This model can store 40 kWh of electricity, and has a matching "Huawei Household Charging Pile", which supports fast charging (45 minutes can make the power from 20% to 80%, and 5 hours of slow charging can make the power from 20% to 80%), and of course it can also generate electricity from gasoline (56L fuel tank), and it can also output 3500W(220V) AC power to the outside world. Super fast charging charging charging charging treasure, four-wheel drive flagship version 110.

It is reported that the interior car of AITO’s M5 is a 15.9-inch 2K HDR screen, with 90% screen ratio, 128-color RGB atmosphere lights and seamless panoramic canopy.

In addition, this model also has built-in Huawei Sound’s top luxury audio system and a car audio with a peak of 1200 watts. It is worth mentioning that Huawei also has a high-quality cockpit music experience, providing a 10-million-level music library and a high-quality music area for Huawei music, and supporting the playback of lossless music with 5.1 channels and 7.1 channels.

In other aspects, AITO Wujie M5 comes with its own fragrance system, which claims to have the fastest charging in the car, 66W wired fast charging and 40W wireless fast charging, with five charging interfaces of 1A4C, as well as the advanced crystal diamond handle, the co-pilot’s "Queen’s fill lens", center speaker, 19-unit vocal design, ventilated heating massage seat, Napa leather, HUD head-up display function and so on.

Finally, AITO M5 also provides Huawei Card Owner’s Courtesy Edition, covering the whole life cycle from car purchase to car use, providing preferential installment service and rich owner’s rights and interests. With the owner card of Huawei Card, you can enjoy the owner’s rights and services. In Huawei wallet App, car owners can quickly apply for cards, handle car staging, enjoy cash back and driver accident insurance on the whole line, and create a variety of smart car scenes.